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Sumithra, M.
- Pharmacological Evaluation of Polyherbal Formulation for Nephroprotective Activity
Abstract Views :161 |
PDF Views:89
Authors
Affiliations
1 R&D Centre, Rumi Herbals Private Limited, Chennai – 600095, Tamil Nadu, IN
2 Department of Pharmacology, SRM College of Pharmacy, SRMIST, Kattankulathur – 603203, Tamil Nadu, IN
3 Department of Pharmacology, College of Pharmacy, Madras Medical College, Chennai – 600003, Tamil Nadu, IN
4 Department of Pharmacology, Captain Srinivasa Murthy Regional Ayurveda Drug Development Institute, Chennai – 600106, Tamil Nadu, IN
1 R&D Centre, Rumi Herbals Private Limited, Chennai – 600095, Tamil Nadu, IN
2 Department of Pharmacology, SRM College of Pharmacy, SRMIST, Kattankulathur – 603203, Tamil Nadu, IN
3 Department of Pharmacology, College of Pharmacy, Madras Medical College, Chennai – 600003, Tamil Nadu, IN
4 Department of Pharmacology, Captain Srinivasa Murthy Regional Ayurveda Drug Development Institute, Chennai – 600106, Tamil Nadu, IN
Source
Journal of Natural Remedies, Vol 22, No 3 (2022), Pagination: 393 - 411Abstract
The kidney plays an essential role in removing waste products and drugs from the body and maintaining balanced body fluids. It gets affected due to many factors, notably, diabetes and high blood pressure. Nowadays, naturally, derived products are essential in curing various ailments and are safe and cost-effective. The purpose of this study is to assess the toxicity profile and nephroprotective effect of a proprietary polyherbal formulation in Wistar albino rats for gentamicin-induced nephrotoxicity. The Polyherbal formulation was procured from Rumi Herbals Private Limited. Acute toxicity experiments were conducted in Wistar rats using the Gentamicin induced nephrotoxicity model as per OECD standards 423, and the efficacy was assessed using the Gentamicin induced nephrotoxicity model. The formulation was proven safe up to 2000mg/ kg orally in an acute toxicity study, with no behavioral abnormalities and no fatality. The gentamicin 80 mg/kg i.p for 7 days induced nephrotoxicity in rats showed a significant (P<0.05) increase in the renal parameters and reduction in antioxidant levels compared with day 0. Whereas test drug-treated groups at a low dose (200 mg/kg) and high dose (400 mg/kg) showed significant (P<0.05) reduction in elevated renal parameters and improvement in antioxidant levels compared with the disease control group. According to the histopathological interpretation of isolated kidneys, this formulation protects from kidney damage and restores typical kidney architecture. From the results, the proprietary polyherbal formulation has shown effective nephroprotective activity may be due to the presence of secondary metabolites/phytoconstituents. Further investigation is essential to focus on the mechanism involved and standardize the active phytoconstituents responsible for the nephroprotective activity.
Keywords
Acute Toxicity, Antioxidant, Gentamicin, Nephroprotective, Polyherbal Formulation.Full Text
References
- Malik HMA. Treatment through herbs. Medicinal plants of Pakistan. 2001; 6(3):21–3.
- Sigerist HE . A history of medicine, Volume I, Oxford University Press, London; 1951. p. 47–9.
- California. European markets for urinary stone removal devices and equipment report. Life Science Intelligence. 2008:453.
- Boneses RN, Taussk HA. On the colorimetric determi- nation of creatinine by the Jaffe reaction. J Biol Chem. 1945; 158:581–91. https://doi.org/10.1016/S0021- 9258(19)51334-5
- Natelson S. Micro-techniques of clinical chemistry for the routine laboratory. Spring-Field, Illinois; 1957. p. 381.
- Fossati P, Prencipe L, Berti G., Use of 3, 5-dichloro- 2-hydroxy benzene sulfonic and/4-aminophenazone chromogenic system in direct enzymic assay of uric acid in serum and urine. Clin Chem. 1980; 26:227–31. https://doi. org/10.1093/clinchem/26.2.227. PMid:7353268
- Fawcett JK, Scott JE. A rapid and precise method for the determination of urea. J Clin Pathol. 1960; 13(2):156–9. https://doi.org/10.1136/jcp.13.2.156. PMid:13821779. PMCid:PMC480024
- Lowry OH, Rosenbrough NJ, Farr AL, Randall RJ., Protein measurement with the Folin’s reagent. J Biol Chem. 1951, 193:26–76. https://doi.org/10.1016/S0021-9258(19)52451-6
- Doumas BT, Biggs HG, Arends RL, Pinto PVC. Determination of Serum Albumin. Based on the methods of Rodkey (1), Bartholomew and Delaney (2), and Doumas, Watson, and Biggs (3)., Editor(s): Gerald R. Cooper, Standard Methods of Clinical Chemistry, Elsevier, Volume 7; 1972. p. 175–88. https://doi.org/10.1016/B978-0-12- 609107-6.50022-2
- Maruna RF, Jrinder SR. Determination of serum sodium by colorimetric method. Clin Chem. 1958.
- Maruna RFL., Determination of serum potassium by colo- rimetric method. Clinicachemicaacta. 1957; 2(2):131–3. https://doi.org/10.1016/0009-8981(57)90093-1
- Fiske CH, Subbarrow. The colorimetric determination of phosphorus. J Biol Chem. 1925; 66:375–400. https://doi. org/10.1016/S0021-9258(18)84756-1
- Dacie JV, Lewis SM. Practical Haematology, 4th edition J and A, Churchill, UK; 1968. p. 37.
- Beuge JA, Aust SD. The thiobarbituric acid assay. Meth Enzymol. 1978; 52:306–7.
- Kakkar P, Das B, Viswanathan PN. A modified spectropho- tometric assay of superoxide dismutase. Indian J Biochem Biophys. 1984; 21(2):130–2.
- Beers R, Sizer I. A spectrophotometric method for measur- ing the breakdown of hydrogen peroxide by catalase. J Biol Chem. 1952; 195:133–42. https://doi.org/10.1016/S0021- 9258(19)50881-X
- Rotruck JT, Pope AL, Ganther HE. Selenium: Biochemical roles as component of glutathione peroxidase. Science. 1973; 179:588–90. https://doi.org/10.1126/science.179.4073.588. PMid:4686466
- Moron MS, Dse Pierre JW, Manerwik KB. Levels of gluta- thione, glutathione reductase and glutathione-s-transferase activities in rat lung and liver. Biochim Biophys Acta. 1978, 582:67–8. https://doi.org/10.1016/0304-4165(79)90289-7
- Gowda S, Desai PB, Kulkarni SS, Hull VV, Math AA, Vernekar SN. Markers of renal function tests. N Am J Med Sci. 2010; 2(4):170–3.
- Weiner ID, Mitch WE, Sands JM. Urea and ammonia metabolism and the control of renal nitrogen excretion. Clin J Am Soc Nephrol. 2015; 7;10(8):1444–58. https:// doi.org/10.2215/CJN.10311013. PMid:25078422. PMCid:PMC4527031
- De Oliveira EP, Burini RC. High plasma uric acid con- centration: Causes and consequences. Diabetol Metab Syndr. 2012; 4:12. https://doi.org/10.1186/1758-5996-4-12. PMid:22475652. PMCid:PMC3359272
- Martin WF, Armstrong LE, Rodriguez NR. Dietary protein intake and renal function. Nutr Metab (Lond). 2005; 20; 2:25. https://doi.org/10.1186/1743-7075-2-25. PMid:16174292. PMCid:PMC1262767
- Hermann, Janice R. Protein and the Body (PDF). Oklahoma Cooperative Extension Service, Division of Agricultural Sciences and Natural Resources. Oklahoma State University. p. T-3163-1–4.
- Gounden V, Vashisht R, Jialal I. Hypoalbuminemia. 2021. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022. PMID: 30252336.
- Busher JT. Serum albumin and globulin. In: Walker HK, Hall WD, Hurst JW, (editors). Clinical methods: The his- tory, physical, and laboratory examinations. 3rd edition. Boston: Butterworths; 1990. Chapter 101.
- Padugupati S, Kumar KK, Vasantha L, Sarma D. Study of serum protein and electrophoretic pattern in pumon- arytuberculosis patients. Int J Clin Biochem Res. 2018; 5(3):353–60 https://doi.org/10.18231/2394-6377.2018.0074
- Strazzullo P, Leclercq C. Sodium. Adv Nutr. 2014; 1; 5(2):188–90. https://doi.org/10.3945/an.113.005215. PMid:24618759. PMCid:PMC3951800
- Clase CM, Carrero JJ, Ellison DH, Grams ME, Hemmelgarn BR, Jardine MJ, et al. Potassium homeostasis and manage- ment of dyskalemia in kidney diseases: Conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference. Kidney Int. 2020; 97(1):42–61. https://doi.org/10.1016/j.kint.2019.09.018. PMid:31706619
- Fourtounas C. Phosphorus metabolism in chronic kidney disease. Hippokratia. 2011; 5(Suppl 1):50–2.
- Obeagu, Emmanuel. Erythropoietin and Kidney Diseases: A Review. 2016; 33:760–92.
- Ayala A, Muñoz MF, Argüelles S. Lipid peroxidation: production, metabolism, and signaling mechanisms of malondialdehyde and 4-hydroxy-2-nonenal. Oxid Med Cell Longev. 2014. https://doi.org/10.1155/2014/360438. PMid:24999379. PMCid:PMC4066722
- Younus H. Therapeutic potentials of superoxide dismutase. Int J Health Sci (Qassim). 2018; 12(3):88–93.
- Nandi A, Yan LJ, Jana CK, Das N. Role of catalase in oxidative stress- and age-associated degenerative diseases. Oxid Med Cell Longev. 2019; 11. https://doi.org/10.1155/2019/9613090. PMid:31827713. PMCid:PMC6885225
- Altuhafi A, Altun M, Hadwan MH. The correlation between selenium-dependent glutathione peroxidase activity and oxidant/antioxidant balance in sera of diabetic patients with nephropathy. Rep Biochem Mol Biol. 2021; 10(2):164–72. https://doi.org/10.52547/rbmb.10.2.164. PMid:34604406. PMCid:PMC8480288
- Lushchak, Volodymyr. Glutathione homeostasis and functions: Potential targets for medical interventions. J Amino Acids. 2012. https://doi.org/10.1155/2012/736837. PMid:22500213. PMCid:PMC3303626
- Formulation, Standardization, and Preclinical Evaluation of Polyherbal Suspension against Inflammatory Bowel Disease
Abstract Views :152 |
PDF Views:91
Authors
Prerna Dubey
1,
Rukaiah Fatma Begum
2,
V. Chitra
2,
R. Mrinalini
2,
Harini Gunasekaran
3,
M. Sumithra
2
Affiliations
1 QVIA RDS (India) Private Limited, Bangalore – 560103, Karnataka, IN
2 Department of Pharmacology, SRM College of Pharmacy, SRMIST, Kattankulathur, Chengalpattu – 603203, Tamil Nadu, IN
3 Labcorp Scientific Services and Solutions Private Limited, Mumbai – 400093, Maharashtra, IN
1 QVIA RDS (India) Private Limited, Bangalore – 560103, Karnataka, IN
2 Department of Pharmacology, SRM College of Pharmacy, SRMIST, Kattankulathur, Chengalpattu – 603203, Tamil Nadu, IN
3 Labcorp Scientific Services and Solutions Private Limited, Mumbai – 400093, Maharashtra, IN
Source
Journal of Natural Remedies, Vol 22, No 3 (2022), Pagination: 412 - 423Abstract
The pharmacological healing for inflammatory bowel diseases continues to be uncertain and requires immediate therapeutic interventions. A poly-herbal formulation obtained from a traditional and authentic classic text of Ayurveda was assessed for its effect against IBD (inflammatory bowel disease) in this study. The formulated poly-herbal suspension comprises three different drugs namely, Burma dhaniya (Eryngium foetidum), Sapota (Manilkara zapota), and Curry leaves (Murraya koenigii). The formulated suspension was evaluated for certain standard parameters like organoleptic and accelerated stability studies at various temperatures. It was checked for its efficacy by oral route in acetic acid-induced colitis affected Balb/c mice. Mice were orally administered with formulated suspension (275 mg/kg, 550 mg/kg,), every 24 hours for 10 days. Histopathology, macroscopic damage score, myeloperoxidase (MPO) activity, and red blood cell parameters were evaluated after treatment. Reduction in the MPO activity, decrease in the macroscopic damage scores, and an increase in RBC cell count were seen distinctly at a high dose of 550 mg/Kg. The results obtained, established the effectiveness of the poly-herbal suspension against inflammatory bowel disease by treating the mice from acetic acid-induced colitis by reducing inflammation and oxidative damage to the colon. The maximum therapeutic effective activity was found to be 550 mg/kg for IBD mice.
Keywords
Acetic Acid, Inflammatory Bowel Disease, Myeloperoxidase, Polyherbal Suspension, Ulcerative Colitis.Full Text
References
- Salminen S, Bouley C, Boutron MC, Cummings JH, Franck A, Gibson GR, et al. Functional food science and gas- trointestinal physiology and function. Br J Nutr. 1998; 80(S1):S147–71. https://doi.org/10.1079/BJN19980108. PMid:9849357
- Riddle MS, Tribble DR, Cachafiero SP, Putnam SD, Hooper TI. Development of a travelers’ diarrhea vaccine for the mil- itary: How much is an ounce of prevention really worth?. Vaccine. 2008; 26(20):2490–502. https://doi.org/10.1016/j. vaccine.2008.03.008. PMid:18417259
- Loddo I, Romano C. Inflammatory bowel disease: genet- ics, epigenetics, and pathogenesis. Front Immunol. 2015; 6:551. https://doi.org/10.3389/fimmu.2015.00551. PMid:26579126. PMCid:PMC4629465
- Schicho R, Shaykhutdinov R, Ngo J, Nazyrova A, Schneider C, Panaccione R, et al. Quantitative metabolomic profil- ing of serum, plasma, and urine by 1H NMR spectroscopy discriminates between patients with inflammatory bowel disease and healthy individuals. J. Proteome Res. 2012; 11(6):3344–57. https://doi.org/10.1021/pr300139q. PMid:22574726. PMCid:PMC3558013
- Mu L, Liu L, Niu R, Zhao B, Shi J, Li Y, et al. Indoor air pollution and risk of lung cancer among Chinese female non-smokers. Cancer Causes and Control. 2013; 24(3):439–50. https://doi.org/10.1007/s10552-012-0130-8. PMid:23314675. PMCid:PMC3574203
- Vojinovic J. Vitamin D receptor agonists’ anti‐inflammatory properties. Ann N Y Acad Sci. 2014; 1317(1):47–56. https:// doi.org/10.1111/nyas.12429. PMid:24754474
- Yamamoto T, Nakahigashi M, Saniabadi AR. Review arti- cle: diet and inflammatory bowel disease-epidemiology and treatment. Aliment Pharmacol Ther. 2009; 30(2):99– 112. https://doi.org/10.1111/j.1365-2036.2009.04035.x. PMid:19438426
- Kaufmann WE, Worley PF, Pegg J, Bremer M, Isakson P. COX-2, a synaptically induced enzyme, is expressed by excitatory neurons at postsynaptic sites in rat cerebral cortex. Proc Natl Acad Sci U.S.A. 1996; 93(6):2317–21. https://doi.org/10.1073/pnas.93.6.2317. PMid:8637870. PMCid:PMC39793
- Ricciotti E, FitzGerald GA. Prostaglandins and inflamma- tion. Arterioscler Thromb Vasc Biol. 2011; 31(5):986–1000. https://doi.org/10.1161/ATVBAHA.110.207449. PMid:21508345. PMCid:PMC3081099
- Izard CE. Four systems for emotion activation: Cognitive and noncognitive processes. Psychol Rev. 1993; 100(1):68. https://doi.org/10.1037/0033-295X.100.1.68. PMid:8426882
- Miller GE, Chen E, Zhou ES. If it goes up, must it come down? Chronic stress and the hypothalamic-pituitary-adrenocor- tical axis in humans. Psychol Bull. 2007; 133(1):25. https:// doi.org/10.1037/0033-2909.133.1.25. PMid:17201569
- Gowri SS, Vasantha K. Phytochemical screening and anti- bacterial activity of Syzygium cumini (L.)(Myrtaceae) leaves extracts. Int J Pharm Tech Res. 2010; 2(2):1569–73.
- Farnsworth NR. Biological and phytochemical screening of plants. J Pharm Sci. 1966; 55(3):225–76. https://doi. org/10.1002/jps.2600550302. PMid:5335471
- Niu X, Fan T, Li W, Huang H, Zhang Y, Xing W. Protective effect of sanguinarine against acetic acid-induced ulcer- ative colitis in mice. Toxicol Appl Pharmacol. 2013; 267(3):256–65. https://doi.org/10.1016/j.taap.2013.01.009. PMid:23352506
- Krawisz JE, Sharon P, Stenson WF. Quantitative assay for acute intestinal inflammation based on myeloperoxidase activity: Assessment of inflammation in rat and hamster models. Gastroenterology. 1984; 87(6):1344–50. https://doi. org/10.1016/0016-5085(84)90202-6
- Tsikas D. Analysis of nitrite and nitrate i biological flu- ids by assays based on the Griess reaction: Appraisal of the Griess reaction in the l-arginine/nitric oxide area of research. J Chromatogr B. 2007; 851(1–2):51–70. https:// doi.org/10.1016/j.jchromb.2006.07.054. PMid:16950667
- Masoodi I, Kochhar R, Dutta U, Vaishnavi C, Prasad KK, Vaiphei K, et al. Fecal lactoferrin, myeloperoxidase and serum C-reactive are effective biomarkers in the assess- ment of disease activity and severity in patients with idiopathic ulcerative colitis. J Gastroenterol Hepatol. 2009; 24(11):1768–74. https://doi.org/10.1111/j.1440- 1746.2009.06048.x. PMid:20136960
- Lih-Brody L, Powell SR, Collier KP, Reddy GM, Cerchia R, Kahn E, et al. Increased oxidative stress and decreased anti- oxidant defenses in mucosa of inflammatory bowel disease. Dig Dis Sci. 1996; 41:2078–86. https://doi.org/10.1007/ BF02093613. PMid:8888724
- Krawisz JE, Sharon P, Stenson WF. Qualitative assay for acute intestinal inflammation based on myeloperoxidase activity. Gastroenterology. 1984; 87:1344–50. https://doi.org/10.1016/0016-5085(84)90202-6
- Arnhold J. Properties, functions and secretion of human myeloperoxidase. Biochemistry. 2004; 69:4–9. https://doi.org/10.1023/B:BIRY.0000016344.59411.ee. PMid:14972011
- Elson CO, Sartor RB, Tennyson GS, Riddell RH. Experimental models of inflammatory bowel disease. Gastroenterology. 1995; 109:1344–67. https://doi.org/10.1016/0016-5085(95)90599-5
- Sharon P, Stenson WF. Metabolism of arachidonic acid in acetic acid colitis in rats. Gastroenterology. 1985; 88:55–63.https://doi.org/10.1016/S0016-5085(85)80132-3
- McQuaid KR. Drug used in treatment of gastrointestinal disease. In: Katzung BG, Master SB, Trever AJ, editors. Basic and Clinical Pharmacology. 12th ed. New York: McGraw Hill- Lange; 2012. p. 1081–108.
- Billerey- Larmonier C, Uno JK, Larmonier N, Midura AJ, Timmermann B, Ghishan FK, et al. Protective effects of dietary curcumin in mouse model of chemically induced colitis are strain dependent. Inflamm Bowel Dis. 2008; 14(6):780–93. https://doi.org/10.1002/ibd.20348 PMid:18200517. PMCid:PMC4427520
- Calixto JB. Efficacy, safety, quality control, marketing and regulatory guidelines for herbal medicines (phytothera- peutic agents). Braz J Med Biol Res. 2000; 33(2):179–89. https://doi.org/10.1590/S0100-879X2000000200004. PMid:10657057
- Rodrigues TLM, Castro GLS, Viana RG et al. Physiological performance and chemical compositions of the Eryngium foetidumL.(Apiaceae)essentialoilcultivatedwithdifferent fertilizer sources. Nat Prod Res. 2021; 35:5544–8. https:// doi.org/10.1080/14786419.2020.1795653. PMid:32691619
- Fayek NM, Monem AR, Mossa MY, Meselhy MR, Shazly AH. Chemical and biological study of Manilkara zapota (L.) van Royen leaves (Sapotaceae) cultivated in Egypt. Pharmacognosy Res. 2012; 4:85–91. https:// doi.org/10.4103/0974-8490.94723. PMid:22518080. PMCid:PMC3326762
- Srinivasan K. Role of spices beyond food flavoring: Nutraceuticals with multiple health effects. Food Rev Int. 200; 21:167–88. https://doi.org/10.1081/FRI-200051872
- Topical Application of Ursolic Acid Cream Ameliorates Imiquimod-induced Plaque Psoriasis in BALB/c Mice
Abstract Views :109 |
PDF Views:77
Authors
Affiliations
1 Department of Pharmacy, Harare Institute of Technology, Harare - BE 277, ZW
2 Department of Pharmacology, SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur - 603203, Tamil Nadu, IN
1 Department of Pharmacy, Harare Institute of Technology, Harare - BE 277, ZW
2 Department of Pharmacology, SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur - 603203, Tamil Nadu, IN
Source
Journal of Natural Remedies, Vol 23, No 1 (2023), Pagination: 79-87Abstract
The valued studies of alternative psoriasis treatment options are in a much higher need among the Scientific Community. This study aimed to evaluate the anti-psoriatic activity of ursolic acid cream in imiquimod-induced psoriasis in BALB/c mice. The creams containing ursolic acid, a pentacyclic triterpenoid at percentages of 0.1 and 0.2% were formulated. The pH, spreadability, physical characteristics and acute dermal irritation of the cream were assessed. Animals were grouped into five each having 6 animals. Clobetasol, a topical corticosteroid, was used as the standard. One group was used as control and four groups were treated with the formulated imiquimod cream while receiving treatment. Parameters such as skin inflammation severity, ear thickness, plasma level of interleukins (IL)-17, histology of the back of the skin and spleen weight were evaluated. Erythema and scales were scored on a daily basis with the 0.1 and 0.2% ursolic acid cream significantly ameliorating psoriatic-like symptoms in a manner comparable to clobetasol. Imiquimod-induced epidermal hyperplasia and inflammation were inhibited by topical application of ursolic acid as shown by the results of histopathology. Spleens of the positive control group were larger in comparison with the rest of the groups. BALB/c mice treated with ursolic acid creams exhibited a decrease in the plasma levels of cytokines IL-17 when compared to the positive control group. The result of this study provided an insight that topical application of ursolic acid can be a potential treatment for psoriasis.Keywords
Imiquimod, Inflammation, Interleukin-17, Psoriasis, Ursolic AcidFull Text
References
- Thomas PS, Pathology VK. Philadelphia, Pa. Blakiston's son; 2007.
- Dipiro JT, Talbert RL, Yee GC, Matzke GR, Wells BG, Posey LM. Pharmacotherapy: A Pathophysiologic Approach, ed. Connecticut: Appleton and Lange. 2014; 4:141-2.
- Walker R. Clinical pharmacy and therapeutics E-Book. Elsevier Health Sciences; 2011; Oct 24.
- Hammer GD, McPhee SJ, Education MH, editors. Pathophysiology of disease: an introduction to clinical medicine. McGraw-Hill Education Medical; 2014.
- Schon MP, Boehncke WH, Brocker EB. Psoriasis: clinical manifestations, pathogenesis and therapeutic perspectives. Discov Med. 2009; 5(27):253-8.
- Naldi L. Psoriasis and smoking: links and risks. Psoriasis (Auckland, NZ). 2016; 6:65. https://doi.org/10.2147/PTT. S85189
- Casciano F, Pigatto PD, Secchiero P, Gambari R, Reali E. T cell hierarchy in the pathogenesis of psoriasis and associated cardiovascular comorbidities. Front Immunol. 2018; 9:1390. https://doi.org/10.3389/fimmu.2018.01390
- Lowes MA, Bowcock AM, Krueger JG. Pathogenesis and therapy of psoriasis. Nature. 2007; 445(7130):866-73. https://doi.org/10.1038/nature05663
- Vena GA, Vestita M, Cassano N. Psoriasis and cardiovascular disease. Dermatol. Ther. 2010; 23(2):144-51. https://doi. org/10.1111/j.1529-8019.2010.01308.x
- Fernandez-Armenteros JM, Gomez-Arbones X, Buti-Soler M, Betriu-Bars A, Sanmartin-Novell V, Ortega-Bravo M, Martínez-Alonso M, Gari E, Portero-Otín M, SantamariaBabi L, Casanova-Seuma JM. Psoriasis, metabolic syndrome and cardiovascular risk factors. A population-based study. J Eur Acad Dermatol Venereol. 2019; 33(1):128-35. https:// doi.org/10.1111/jdv.15159
- Kim WB, Jerome D, Yeung J. Diagnosis and management of psoriasis. CFP. 2017; 63(4):278-85.
- Afifi T, de Gannes G, Huang C, Zhou Y. Topical therapies for psoriasis: Evidence-based review. CFP. 2005; 51(4):519-25.
- Kang SY, Yoon SY, Roh DH, Jeon MJ, Seo HS, Uh DK, Kwon YB, Kim HW, Han HJ, Lee HJ, Lee JH. The antiarthritic effect of ursolic acid on zymosan-induced acute inflammation and adjuvant-induced chronic arthritis models. J Pharm Pharmacol. 2008; 60(10):1347-54. https:// doi.org/10.1211/jpp.60.10.0011
- Murphy BT, MacKinnon SL, Yan X, Hammond GB, Vaisberg AJ, Neto CC. Identification of triterpene hydroxycinnamates with in vitro antitumor activity from whole cranberry fruit (Vaccinium macrocarpon). J Agric Food Chem. 2003; 51(12):3541-5. https://doi.org/10.1021/jf034114g
- Wozniak L, Skapska S, Marszalek K. Ursolic acid-a pentacyclic triterpenoid with a wide spectrum of pharmacological activities. Molecules. 2015; 20(11):20614- 41. https://doi.org/10.3390/molecules201119721
- Ikeda Y, Murakami A, Ohigashi H. Ursolic acid: An antiand pro-inflammatory triterpenoid. Mol Nutr Food Res. 2008; 52(1):26-42. https://doi.org/10.1002/mnfr.200700389
- Liu W, Tan X, Shu L, Sun H, Song J, Jin P, Yu S, Sun M, Jia X. Ursolic acid inhibits cigarette smoke extract-induced human bronchial epithelial cell injury and prevents development of lung cancer. Molecules. 2012; 17(8):9104- 15. https://doi.org/10.3390/molecules17089104
- Sultana N. Clinically useful anticancer, antitumor, and antiwrinkle agent, ursolic acid and related derivatives as medicinally important natural product. J Enzyme Inhib Med Chem. 2011; 26(5):616-42. https://doi.org/10.3109/14 756366.2010.546793
- Do Nascimento PG, Lemos TL, Bizerra A, Arriaga A, Ferreira DA, Santiago GM, Braz-Filho R, Costa JG. Antibacterial and antioxidant activities of ursolic acid and derivatives. Molecules. 2014; 19(1):1317-27. https://doi. org/10.3390/molecules19011317
- Jin YR, Jin JL, Li CH, Piao XX, Jin NG. Ursolic acid enhances mouse liver regeneration after partial hepatectomy. Pharm Biol. 2012; 50(4):523-8. https://doi.org/10.3109/13880209.2 011.611143
- Nema RK, Rathore KS, Dubey BK. Textbook of cosmetics. CBS Publishers and Distributors; 2009.
- Dhyani A, Chander V, Singh N. Formulation and evaluation of multipurpose herbal cream. J Drug Deliv Ther. 2019; 9(2):341-3. https://doi.org/10.22270/jddt.v9i2.2540
- OECD Guideline: OECD 404.
- Sun J, Zhao Y, Hu J. Curcumin inhibits imiquimod-induced psoriasis-like inflammation by inhibiting IL-1beta and IL-6 production in mice. PloS one. 2013; 8(6):e67078. https:// doi.org/10.1371/journal.pone.0067078
- Dou R, Liu Z, Yuan X, Xiangfei D, Bai R, Bi Z, Yang P, Yang Y, Dong Y, Su W, Li D. PAMs ameliorates the imiquimodinduced psoriasis-like skin disease in mice by inhibition of translocation of NF-κB and production of inflammatory cytokines. PLoS One. 2017; 12(5):e0176823. https://doi. org/10.1371/journal.pone.0176823
- Zhao J, Di T, Wang Y, Wang Y, Liu X, Liang D, Li P. Paeoniflorin inhibits imiquimod-induced psoriasis in mice by regulating Th17 cell response and cytokine secretion. Eur J Pharmacol. 2016; 772:131-43. https://doi.org/10.1016/j. ejphar.2015.12.040
- Chen YH, Wu CS, Chao YH, Lin CC, Tsai HY, Li YR, Chen YZ, Tsai WH, Chen YK. Lactobacillus pentosus GMNL-77 inhibits skin lesions in imiquimod-induced psoriasis-like mice. J Food Drug Anal. 2017; 25(3):559-66. https://doi. org/10.1016/j.jfda.2016.06.003
- Kuchekar S, Bhise K. Formulation and development of antipsoriatic herbal gelcream. J Sci Ind Res. 2012; 71(4):279- 284.
- Gilliet M, Conrad C, Geiges M, Cozzio A, Thürlimann W, Burg G, Nestle FO, Dummer R. Psoriasis triggered by toll-like receptor 7 agonist imiquimod in the presence of dermal plasmacytoid dendritic cell precursors. Arch Dermatol. 2004; 140(12):1490-5. https://doi.org/10.1001/ archderm.140.12.1490
- Van Der Fits L, Mourits S, Voerman JS, Kant M, Boon L, Laman JD, Cornelissen F, Mus AM, Florencia E, Prens EP, Lubberts E. Imiquimod-induced psoriasis-like skin inflammation in mice is mediated via the IL-23/IL-17 axis. J Immunol. 2009; 182(9):5836-45. https://doi.org/10.4049/ jimmunol.0802999
- Sonja Moos, Alma N Mohebiany, Ari Waisman Florian C. Kurschus. Imiquimod-Induced Psoriasis in Mice Depends on the IL-17 Signaling of Keratinocytes. J Invest Dermatol. 2019; 139(5):1110-1117. https://doi.org/10.1016/j. jid.2019.01.006
- Thaci D, Humeniuk J, Frambach Y, Bissonnette R, Goodman JJ, Shevade S, Gong Y, Papavassilis C, STATURE Study Group. Secukinumab in psoriasis: randomized, controlled phase 3 trial results assessing the potential to improve treatment response in partial responders (STATURE). British Journal of Dermatology. 2015; 173(3):777-87. https://doi.org/10.1111/bjd.13814